Fruits and Veggies Decrease Cardiovascular Disease

Heiss C et al. – Diet is a major lifestyle factor in the primary and secondary prevention of numerous chronic diseases, including myocardial infarction, stroke, and diabetes. Epidemiological studies suggest that the beneficial cardiovascular health effects of diets rich in fruits and vegetables are in part mediated by their flavonoid content, with particular benefits provided by one member of this family, the flavanols. This concept is supported by findings from small–scale intervention studies with surrogate endpoints including endothelium–dependent vasodilation, blood pressure, platelet function, and glucose tolerance. Mechanistically, short–term effects on endothelium–dependent vasodilation following the consumption of flavanol–rich foods, as well as purified flavanols, have been linked to an increased nitric oxide bioactivity in healthy humans, and those with increased cardiovascular risk.

European Heart Journal, 09/21/2010
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Interested in living a healthier lifestyle with diet, exercise and hormone replacement? Evolve Medical and Joel Nathan, MD can answer your questions.

Either Low-Carb or Low-Fat Diets Work Well

Decreasing intake of carbohydrates or fats leads to the same weight loss over time. However, the low-carb approach increases HDL Cholesterol levels (the “good” cholesterol). This is according to an Annals of Internal Medicine Study.

Weight loss was virtually identical on both diets.

Interested in living a healthier lifestyle with diet, exercise and hormone replacement? Evolve Medical and Joel Nathan, MD can answer your questions.

Score Another Positive Effect of Vitamin D for a Healthy Nervous System

Two studies seem to point to vitamin D deficiency as having a role in both cognitive decline and Parkinson disease, but commentators aren’t certain about the clinical implications.

One study, published in the Archives of Internal Medicine, followed some 850 older adults for about 6 years. Low serum levels of vitamin D at the outset of the study were associated with substantial cognitive decline by study’s end. Experts caution that “low vitamin D levels may simply be a marker for lower health status than a cause of it.” They write that “a rigorous evidence base … does not currently exist” to favor using vitamin D supplementation to improve health outcomes.

The other study, published in the Archives of Neurology, found an association between low levels of vitamin D and the development of Parkinson disease by follow-up some 30 years later. These results are prelimiary.


Interested in leading a healthier lifestyle with diet, exercise and hormone replacement? Evolve Medical and Joel Nathan, MD can answer your questions.

Warming Up and Cooling Down

warming upYou should include warm-up and cool-down exercises before and after exercise. Muscles that have not been used are cool. Doing calisthenics and dynamic stretching or walking slowly for 5 to 10 minutes before beginning your workout warms your muscles, making them more flexible and less prone to injury.

Right after exercise, allow your heart rate to return slowly to normal. Walking slowly, for example, will let you cool down and let your heart and breathing to return to normal levels. You should also stretch the muscles you used during your exercise. Devote a total of 5 to 10 minutes to cooling down.

Interested in leading a healthier lifestyle with diet, exercise and hormone replacement? Evolve Medical and Joel Nathan, MD can answer your questions.

What’s the Skinny on Skin

Skin changes are among the most visible signs of aging. Evidence of increasing age includes wrinkles and sagging skin. Whitening or graying of the hair is another obvious sign of aging.

Your skin does many things. It protects you from the environment, helps control your body temperature and fluid and electrolyte balance, and contains nerve receptors that allows you to feel sensations such as touch, pain, and pressure.

Although skin has many layers, it can be generally divided into three main parts.
The outer part (epidermis) contains skin cells, pigment, and proteins.

The middle part (dermis) contains blood vessels, nerves, hair follicles, and oil glands. The dermis provides nutrients to the epidermis.

The inner layer under the dermis (the subcutaneous layer) contains sweat glands, some hair follicles, blood vessels, and fat. Each layer also contains connective tissue with collagen fibers to give support and elastin fibers to provide flexibility and strength.

Skin changes are related to environmental factors, genetic makeup, nutrition, and other factors. The greatest single factor, though, is sun exposure. This can be seen by comparing areas of your body that have regular sun exposure with areas that are protected from sunlight.

Natural pigments seem to provide some protection against sun-induced skin damage. Blue-eyed, fair-skinned people show more aging skin changes than people with darker, more heavily pigmented skin.

AGING CHANGES

With aging, the outer skin layer (epidermis) thins even though the number of cell layers remains unchanged.
The number of pigment-containing cells (melanocytes) decreases, but the remaining melanocytes increase in size. Aging skin thus appears thinner, more pale, and translucent. Large pigmented spots (called age spots, liver spots, or lentigos) may appear in sun-exposed areas.

Changes in the connective tissue reduce the skin’s strength and elasticity. This is known as elastosis and is especially pronounced in sun-exposed areas (solar elastosis). Elastosis produces the leathery, weather-beaten appearance common to farmers, sailors, and others who spend a large amount of time outdoors.
The blood vessels of the dermis become more fragile, which in turn leads to bruising, bleeding under the skin, cherry angiomas, and similar conditions.

Sebaceous glands produce less oil as you age. Men experience a minimal decrease, usually after the age of 80. Women gradually produce less oil beginning after menopause. This can make it harder to keep the skin moist, resulting in dryness and itchiness.

The subcutaneous fat layer, which provides insulation and padding, thins. This increases your risk of skin injury and reduces your ability to maintain body temperature. Because you have less natural insulation and in cold weather, hypothermia can result.

Some medications are absorbed by the fat layer, and loss of this layer changes the way that these medications work.

The sweat glands produce less sweat. This makes it harder to keep cool, and you become at increased risk for becoming overheated or developing heat stroke.

Growths such as skin tags, warts, and other blemishes are more common in older people.

EFFECT OF CHANGES

As you age, you are at increased risk for skin injury. Your skin is thinner, more fragile, and the protective subcutaneous fat layer is lost. In addition, your ability to sense touch, pressure, vibration, heat and cold may be reduced. Thus, your aging skin is at higher risk for injury.

Rubbing or pulling on the skin can cause skin tears. Fragile blood vessels are easily broken. Bruises, flat collections of blood (purpura), and raised collections of blood (hematomas) may form after even a minor injury.

This is most easily seen on the outside surface of the forearms, but can occur anywhere on the body. Skin changes and loss of subcutaneous fat, combined with a tendency to be less active, as well as some nutritional deficiencies and other illnesses contribute to pressure ulcers.

Aging skin repairs itself more slowly than younger skin. Wound healing may be up to 4 times slower. This contributes to pressure ulcers and infections. Diabetes, blood vessel changes, lowered immunity, and similar factors also affect healing.

COMMON PROBLEMS

Skin disorders are so common among older people that it is often difficult to tell normal changes from those related to a disorder. More than 90% of all older people have some type of skin disorder.

Skin disorders can be caused by many diseases including diabetes, liver disease, heart disease, and blood vessel diseases such as arteriosclerosis. Stress, reactions to medications, obesity, and nutritional deficiencies can be other causes.

Climate, exposures to industrial and household chemicals, indoor heating, clothing, allergies to plants, other allergies, and many other common exposures can also cause skin changes.

Sunlight can cause elastosis (loss of elasticity), keratoacanthomas (noncancerous skin growths), thickening of the skin, pigment changes such as liver spots, and other conditions.

Sun exposure has also been directly linked to skin cancers, including basal cell epithelioma, squamous cell carcinoma, and melanoma.

PREVENTION
Because most skin changes are related to sun exposure, prevention is a lifelong process.
• Prevent sunburn if at all possible.
• Use a good quality sunscreen when outdoors, even in the winter.
• Wear protective clothing and hats as necessary.

Good nutrition and adequate fluids are also helpful. Dehydration increases the risk of skin injury. Sometimes minor nutritional deficiencies can cause rashes, skin lesions, and other skin changes even if no other symptoms are present.

Keep skin moist with lotions and do not use soaps that are heavily perfumed. Bath oils are not recommended because they can cause you to slip and fall.

Moist skin is more comfortable and may heal better.

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Get and stay as healthy as possible. Evolve Medical Institute-NY can assess and optimize your health. Affordable, effective and personalized Hormone Replacement Therapy are key reasons patients select our program. Insurance may be used for blood work as well as most prescriptions. Get started now. For free and no obligation information, please call me at 212-410-9800.

Vitamin B6

Definition
Vitamin B6 is a water-soluble vitamin. Water-soluble vitamins dissolve in water. The body cannot store them. Leftover amounts of the vitamin leave the body through the urine. That means you need a continuous supply of such vitamins in your diet.

Alternative Names
Pyridoxine

Function
Vitamin B6 helps the immune system produce antibodies. Antibodies are needed to fight many diseases. Vitamin B6 helps maintain normal nerve function and form red blood cells. The body uses it to help break down proteins. The more protein you eat, the more vitamin B6 you need.

Food Sources
Vitamin B6 is found in beans, nuts, legumes, eggs, meats, fish, whole grains, and fortified breads and cereals.

Side Effects
Large doses of vitamin B6 can cause neurological disorders and numbness. Deficiency of this vitamin can cause mouth and tongue sores, irritability, confusion, and depression. (Vitamin B6 deficiency is not common in the United States.)

Recommendations
The Food and Nutrition Board at the Institute of Medicine recommends the following dietary intake for vitamin B6:

Infants
0 – 6 months: 0.1 milligrams per day (mg/day)
7 – 12 months: 0.3 mg/day

Children
1 – 3 years: 0.5 mg/day
4 – 8 years: 0.6 mg/day
9 – 13 years: 1.0 mg/day

Adolescents and Adults
Males age 14 to 50 years: 1.3 mg/day
Males over 50 years: 1.7 mg/day
Females age 14 to 18 years: 1.2 mg/day
Females age 19 to 50 years: 1.3 mg/day
Females over 50 years: 1.5 mg/day

The best way to get the daily requirement of essential vitamins is to eat a balanced diet that contains a variety of foods from the food guide pyramid.
Specific recommendations depend on age, gender, and other factors (such as pregnancy). Women who are pregnant or producing breast milk (lactating) need higher amounts. Ask your health care provider which amount is best for you.

References
Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, PantothenicAcid, Biotin, and Choline. National Academy Press, Washington, DC, 1998.
Hamrick I, Counts SH. Vitamin and mineral supplements. Wellness and Prevention. December 2008:35(4);729-747.
Rakel D, ed. Integrative Medicine. 2nd ed. Philadelphia, Pa: Saunders Elsevier; 2007.
Mason JB. Vitamins, trace minerals, and other micronutrients. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 237.

Heard of Red Yeast Rice?

Red yeast rice is a naturally occurring substance that contains small amounts of lovastatin, the active ingredient in Mevacor, and a prescription drug used to lower cholesterol. Not only does it lower cholesterol but in one study, it also lowered the risk of subsequent heart attacks by half and death from any cause by one-third.

Red yeast rice comes in capsule form. The dose is 1 gram twice a day.

Got Libido?

Decreased libido may follow conflict in a sexual relationship, or can occur due to reduced frequency of sexual activity from sexual dysfunction. The sexual dysfunction that causes the decreased sexual activity could be such as erectile dysfunction or premature ejaculation. It also appears that a reduced testosterone level is associated with decreased libido in both males and females.

Other causes of decreased libido include depression, liver failure, alcoholism, most antipsychotics and antidepressants and a number of endocrine conditions, notably hypothyroidism, testosterone deficiency and menopause.

Reduced libido may be treated with individual or couples psychotherapy. One preliminary study in females suggested that some patients might improve with bupropion (Welbutrin), regardless of whether depression is present or not.

Specifically, with testosterone deficiency, testosterone replacement is indicated Menopausal patients may benefit from hormone replacement therapy.

What’s Andropause?

Beginning around age 35 years old, men begin to have decreased testosterone levels by 1-3% per year. This gradual decrease in testosterone production leads to what is called andropause. The symptoms of andropause include fatigue (in 80% of men studied), depression (in 70%), irritability and anger (in 60%), reduced libido and erectile dysfunction (in up to 80%), diminished lean muscle mass, and other subtle signs and symptoms of premature aging.

Low testosterone levels have been associated with higher risk of atherosclerosis, low muscle mass, and weight gain from a higher percentage of body fat. Although testosterone therapy may improve sexual function, cognitive abilities, and lean muscle mass, its use should be limited to patients with low baseline testosterone levels. In addition, their prescribing physician must monitor those on hormone replacement regularly. Yearly physical exams and blood work on at least a 3-4 month basis are important to ensure safety and effectiveness of therapy.